Tag: IISc – Indian Institute of Science -Develop Enzymes

KARNATAKA: AI in MEDICINE: Siemens Healthineers opens Precision Medicine Lab at IISc

Siemens Healthineers and IISc inaugurated the Siemens Healthineers-Computational Data Sciences (CDS) Collaborative Laboratory for AI in Precision Medicine at IISc campus in the city.

The laboratory would develop open-source AI-based tools to precisely automate the segmentation of pathological findings in neuroimaging data, with a focus on accurately diagnosing neurological diseases and analysing their clinical impact at a population level, said Peter Schardt, Chief Technology Officer, Siemens Healthineers while inaugurating the lab.

The focus of this collaborative laboratory would be to work closely with neurologists, radiologists and Siemens Healthineers and integrate the developed computational models into their regular clinical workflows, the company said.

Mr. Schardt said, “The collaboration with IISc solidifies our commitment to advancing precision medicine through AI using state-of-the-art, data-driven deep-learning techniques. Leveraging IISc’s academic excellence and our strong core in medical imaging, smart solutions developed through this collaboration will help us ultimately save lives through precise diagnoses and evidence-based treatments”.

Govindan Rangarajan, Director, Indian Institute of Science, said, “This lab marks a crucial step forward in unlocking the potential of AI for precision medicine.”

India was one of the four global innovation hubs for Siemens Healthineers, and the company was committed to being catalysts in interdisciplinary research, stated Dileep Mangsuli, Executive Director, Siemens Healthineers.

“Along with IISc, we aim to reshape the landscape of neuroscientific progress through the capabilities of artificial intelligence, translating laboratory insights into intelligent solutions. We want to empower the broader clinical research community and be changemakers in the fight against world’s most life-threatening diseases,” Mr. Mangsuli added.

source/content: thehindu.com (headline edited)

KARNATAKA: SCIENCE & TECHNOLOGY: RESEARCH / NANOENZYMES: Scientists of Indian Institute of Science (IISc) Develop Enzyme Mimetic with potential applications in Wastewater Treatment, Healthcare

The nanozyme can degrade pollutants in wastewater by oxidising them in the presence of sunlight, thereby reducing the toxicity of wastewater.

Scientists at the Materials Research Centre (MRC), Indian Institute of Science (IISc), have developed a new type of enzyme mimetic that can degrade toxic chemicals in industrial wastewater effectively in the presence of sunlight. 

Enzymes are proteins that catalyse a majority of biological reactions in living systems. However, the practical use of natural enzymes is hindered by inherent limitations such as sensitivity to denaturation (breakdown/damage), complex production procedures, high costs, and difficulties in recycling, says Subinoy Rana, Assistant Professor at MRC and corresponding author of the paper published in Nanoscale. 

Mass producing these enzymes is an expensive and time-consuming process. Another problem is storage – most of the natural enzymes are temperature-sensitive and require storage at cooler temperatures, often as low as -20°C. 

Nano-sized enzyme mimetics or “nanozymes” manufactured in the lab can mimic such natural enzymes and overcome these practical challenges.  

In the current study, the IISc team synthesised a platinum-containing nanozyme called NanoPtA, which can be converted into powder form for industrial use. 

When the NanoPtA comes in contact with wastewater, the benzene rings and long alkyl chains present in the molecule form multiple non-covalent interactions. Individual NanoPtA molecules connect together to form tape-like structures that start emitting light, which is the origin of its oxidising capacity. The nanozyme can then degrade pollutants present in wastewater by oxidising them in the presence of sunlight, thereby reducing the toxicity of wastewater. 

The team found that the nanozyme could degrade even small (micromolar) quantities of common effluents like phenols and dyes within ten minutes when placed under sunlight. The researchers also found that the NanoPtA complex was quite stable, lasting for up to 75 days at room temperature.  

The team believes that the nanozyme can also have applications in healthcare and could be a potentially useful diagnostic tool for neurological and neurodegenerative diseases. 

source/content: thehindu.com (headline edited)