Tag: IISc Bengaluru

NATIONAL / KARNATAKA: SCIENCE & TECHNOLOGY: IISc designs device to make infrared light visible, with diverse applications in defence and optical communications

Researchers at the Indian Institute of Science (IISc) have fabricated a device to increase or up-convert the frequency of short infrared light to the visible range. This up-conversion of light has diverse applications, especially in defence and optical communications, said IISc.

“The human eye can only see light at certain frequencies (called the visible spectrum), the lowest of which constitutes red light. Infrared light, which we can’t see, has an even lower frequency than red light. IISc researchers have now fabricated a device to increase or up-convert the frequency of short infrared light to the visible range,” IISc said.

2D material used

The institute added that in a first, the IISc team used a 2D material to design what they call a non-linear optical mirror stack to achieve this up-conversion, combined with widefield imaging capability. The stack consists of multilayered gallium selenide fixed to the top of a gold reflective surface, with a silicon dioxide layer sandwiched in between.

It said that traditional infrared imaging uses exotic low-energy bandgap semiconductors or micro-bolometer arrays, which usually pick up heat or absorption signatures from the object being studied.

However, existing infrared sensors are bulky and not very efficient. They are also export-restricted because of their utility in defence. There is, therefore, a critical need to develop indigenous and efficient devices.

The method used by the IISc team involves feeding an input infrared signal along with a pump beam onto the mirror stack. The nonlinear optical properties of the material constituting the stack result in a mixing of the frequencies, leading to an output beam of increased (up-converted) frequency, but with the rest of the properties intact. Using this method, they were able to up-convert infrared light of a wavelength of around 1,550 nm to 622 nm visible light. The output light wave can be detected using traditional silicon-based cameras.

Going forward, the researchers plan to extend their work to up-convert light of longer wavelengths. They are also trying to improve the efficiency of the device by exploring other stack geometries.

Worldwide interest

“There is a lot of interest worldwide in doing infrared imaging without using infrared sensors. Our work could be a game-changer for those applications,” said Varun Raghunathan, associate professor, Department of Electrical Communication Engineering.

source/content: thehindu.com (headline edited)

KARNATAKA: AI in MEDICINE: Siemens Healthineers opens Precision Medicine Lab at IISc

Siemens Healthineers and IISc inaugurated the Siemens Healthineers-Computational Data Sciences (CDS) Collaborative Laboratory for AI in Precision Medicine at IISc campus in the city.

The laboratory would develop open-source AI-based tools to precisely automate the segmentation of pathological findings in neuroimaging data, with a focus on accurately diagnosing neurological diseases and analysing their clinical impact at a population level, said Peter Schardt, Chief Technology Officer, Siemens Healthineers while inaugurating the lab.

The focus of this collaborative laboratory would be to work closely with neurologists, radiologists and Siemens Healthineers and integrate the developed computational models into their regular clinical workflows, the company said.

Mr. Schardt said, “The collaboration with IISc solidifies our commitment to advancing precision medicine through AI using state-of-the-art, data-driven deep-learning techniques. Leveraging IISc’s academic excellence and our strong core in medical imaging, smart solutions developed through this collaboration will help us ultimately save lives through precise diagnoses and evidence-based treatments”.

Govindan Rangarajan, Director, Indian Institute of Science, said, “This lab marks a crucial step forward in unlocking the potential of AI for precision medicine.”

India was one of the four global innovation hubs for Siemens Healthineers, and the company was committed to being catalysts in interdisciplinary research, stated Dileep Mangsuli, Executive Director, Siemens Healthineers.

“Along with IISc, we aim to reshape the landscape of neuroscientific progress through the capabilities of artificial intelligence, translating laboratory insights into intelligent solutions. We want to empower the broader clinical research community and be changemakers in the fight against world’s most life-threatening diseases,” Mr. Mangsuli added.

source/content: thehindu.com (headline edited)

NATIONAL: KARNATAKA: SCIENCE & TECHNOLOGLY / VACCINES : IISc Develops Heat-Tolerant Covid-19 Vaccine

A team of scientists has completed pre-clinical trials and is now gearing up for human testing .

India could soon have a new vaccine for the mutating COVID-19 virus to keep the virus at bay. Scientists at the Indian Institute of Science (IISc) have been working on developing a heat-tolerant vaccine that can offer protection against different strains of SARS-CoV-2 which includes both current and future variants. The team has completed pre-clinical trials and is gearing up for the human testing of the vaccine candidate. 

According to scientists the evolving nature of the virus and different mutations, they are not sure if the current vaccines can be helpful. Raghavan Varadarajan, Professor at the Molecular Biophysics Unit (MBU) has been leading this research project in collaboration with Mynvax, a startup since the beginning of the pandemic. 

After analysing various proteins found in the virus, researchers selected two parts of SARS-CoV-2’s spike protein – the S2 subunit and the Receptor Binding Domain (RBD) – for the new vaccine. The S2 subunit is highly conserved – it mutates much less than the S1 subunit, which is the target of most current vaccines. Scientists have also known that the RBD can provoke a strong immune response in the host. The team created a hybrid protein called RS2 by combining these two components, read a statement released by IISc.  

The researchers used mammalian cell lines to study the expression of the hybrid protein. “The protein showed very high levels of expression, and initially I thought that the experiment was not working properly,” said Nidhi Mittal, PhD student at MBU and first author of the study. Further research by Mittal showed that this protein potentially be produced in large quantities.    

The team then tested the effects of the protein in both mice and hamster models. They found that the hybrid protein triggered a strong immune response and provided better protection when compared to vaccines containing the whole spike protein.  

Varadarajan told TNIE that RS2 has better coverage compared to other vaccines. This could be India’s first homegrown vaccine for the JB.1 variant and others as Covaxin developed for the mutation has become inactive. “Post clinical trials the vaccine can be administered to everyone, starting with healthy human bodies. So far in our animal testing we have not seen any side effects but will have to wait for results on humans,” added Varadarajan.

The RS2 antigen can also be stored at room temperature for a month without the need for cold storage, unlike many vaccines in the market which require mandatory cold storage. This would make the distribution and storage of these vaccine candidates much more economical.  

Varadarajan said the vaccine candidate can be tailored to incorporate the RBD region of any new variant of SARS-CoV-2 that might emerge. Its high levels of expression and stability at room temperature can greatly reduce production and distribution costs, making it well-suited for combating COVID-19. “If need be, the vaccine can also be updated as and when the mutation develops over the years,” he added. 

source/content: newindianexpess.com (headline edited0

KARNATAKA: SCIENCE & TECHNOLOGY: RESEARCH / NANOENZYMES: Scientists of Indian Institute of Science (IISc) Develop Enzyme Mimetic with potential applications in Wastewater Treatment, Healthcare

The nanozyme can degrade pollutants in wastewater by oxidising them in the presence of sunlight, thereby reducing the toxicity of wastewater.

Scientists at the Materials Research Centre (MRC), Indian Institute of Science (IISc), have developed a new type of enzyme mimetic that can degrade toxic chemicals in industrial wastewater effectively in the presence of sunlight. 

Enzymes are proteins that catalyse a majority of biological reactions in living systems. However, the practical use of natural enzymes is hindered by inherent limitations such as sensitivity to denaturation (breakdown/damage), complex production procedures, high costs, and difficulties in recycling, says Subinoy Rana, Assistant Professor at MRC and corresponding author of the paper published in Nanoscale. 

Mass producing these enzymes is an expensive and time-consuming process. Another problem is storage – most of the natural enzymes are temperature-sensitive and require storage at cooler temperatures, often as low as -20°C. 

Nano-sized enzyme mimetics or “nanozymes” manufactured in the lab can mimic such natural enzymes and overcome these practical challenges.  

In the current study, the IISc team synthesised a platinum-containing nanozyme called NanoPtA, which can be converted into powder form for industrial use. 

When the NanoPtA comes in contact with wastewater, the benzene rings and long alkyl chains present in the molecule form multiple non-covalent interactions. Individual NanoPtA molecules connect together to form tape-like structures that start emitting light, which is the origin of its oxidising capacity. The nanozyme can then degrade pollutants present in wastewater by oxidising them in the presence of sunlight, thereby reducing the toxicity of wastewater. 

The team found that the nanozyme could degrade even small (micromolar) quantities of common effluents like phenols and dyes within ten minutes when placed under sunlight. The researchers also found that the NanoPtA complex was quite stable, lasting for up to 75 days at room temperature.  

The team believes that the nanozyme can also have applications in healthcare and could be a potentially useful diagnostic tool for neurological and neurodegenerative diseases. 

source/content: thehindu.com (headline edited)

NATIONAL & KARNATAKA: SCEINC & TECHNOLOGY: Indian Institute of Science (IISc) Develops Autopilot System for Drones

The reason for India’s slow progress in this sector is due to the non-availability of essential indigenous electronics components like microcontrollers and sensors at a reasonable cost.

With the exponential rise in drone usage across sectors like industrial applications, agriculture, logistics and defence, the need for indigenous avionics systems has become crucial. In order to reduce dependence on foreign drone technology, the Indian Institute of Science (IISC) has made a significant achievement in the field of unmanned aerial systems. 

The Artificial Intelligence and Robotics Laboratory (AIRL) at IISC announced that the team has successfully developed an indigenous industrial-grade autopilot system for drones. The team said this achievement is the initial step towards the indigenization of avionics systems for drones in India. This feat was possible through the utilization of Indian-made Vega Microcontrollers, developed by the Centre for Development of Advanced Computing (CDAC), as part of the Digital India RISC-V Program (DIR-V). 

The indigenously developed technology will help reduce the reliance on microcontrollers in future drone avionics projects. Professor Suresh Sundaram, Associate Professor at the Department of Aerospace Engineering, who headed the project said, “Our autopilot system, powered by Vega Microcontrollers, showcases the immense potential of homegrown solutions in the unmanned aerial systems domain. We are confident that this breakthrough will pave the way for further advancements in this field and contribute to the growth of the drone ecosystem in India.” 

India’s most used drone technologies which include an unmanned aerial system (UAV) that can help run a basic operation system and forward data to a navigation control unit, are imported from China, US, Israel, and several European countries.

The reason for India’s slow progress in this sector is due to the non-availability of essential indigenous electronics components like microcontrollers and sensors at a reasonable cost. The country also lacks a skilled workforce working on the UAV systems. Using imported tech comes with major security concerns such as hacking and data manipulation.

The country has been on a steady growth towards chip manufacturing and CDAC is a ray of hope in developing world-class microcontrollers. “This move will cut millions of dollars worth of electronics import over the years and make India self-reliant in terms of UAV technology,” said the laboratory. 

source/content: newindianexpress.com (headline edited)