INTERNATIONAL / NATIONAL / KARNATAKA: TECHNOLOGY TRANSFER OF MEDICAL RESEARCH: Sepsis Treatment SUR-101 Developed by Researchers in Bengaluru and Bhubaneswar licensed to Dutch Biotech firm SurvivX

The development of the treatment was announced by C-CAMP director Dr Taslimarif Saiyed at an event with Netherlands PM Mark Rutte last month.

A novel sepsis treatment, called SUR-101, developed collaboratively by the Centre for Cellular and Molecular Platforms (C-CAMP), Bengaluru, and the Institute of Life Sciences, Bhubaneswar, was licensed to Dutch biotech firm SurvivX in the presence of Netherlands Prime Minister Mark Rutte on Thursday.

The development of the technology, presently at the preclinical stage, was announced by Dr Taslimarif Saiyed, director-CEO of C-CAMP, at an event with Rutte on the latter’s visit to Bengaluru on the sidelines of the G20 summit last month.

Sepsis is a life-threatening medical emergency. It happens when an infection that a patient already has triggers a chain reaction throughout the body. According to C-CAMP, existing interventions for sepsis are found to be effective only at the very early onset of sepsis. By modulating the immune response, the current technology allows a longer time window for administering targeted interventions for sepsis.

“Sepsis is a worldwide challenge, with approximately 50 million cases and 11 million sepsis-related deaths worldwide, accounting for 20 per cent of all global deaths. The new compound, called SUR-101, is an immune-stimulating therapeutic in sepsis patients with signs of immune suppression. It could be the first step towards personalization and precision in sepsis medicine that has thus far been treated as a drug discovery problem. The technology presently at the preclinical stage is a discovery by a team of scientists led by Prof Ravindran Balachandran from ILS. It has been translated and co-developed by the translational research group of Dr Saiyed at C-CAMP,” said a media release from the Bengaluru centre, which is an initiative of the Department of Biotechnology, Ministry of Science, Technology and Earth Sciences.

Speaking on the licensing effort, the Dutch ambassador to India, Marisa Gerards, said, “Life sciences & health remains a priority sector for the bilateral cooperation between the Netherlands and India. We have successfully been working in this field for many years, and this new partnership is a great example of what India and the Netherlands can do together. Sepsis is an important global societal challenge, and it is in need of innovative solutions.”

“This is one of the first global technology transfers by C-CAMP of an academic invention developed exclusively in India. We are excited about the partnership with SurvivX, a biotech company in the Netherlands, in the antimicrobial resistance domain. This agreement will be a model in innovation-focused bilateral partnerships that addresses global issues together,” Dr Saiyed said.

SurvivX CEO Remko van Leeuwen said, “Our technology is based on a specific protein excreted by a tropical parasite: the filarial roundworm. The team in India made the remarkable observation that people infected by this parasite typically do not end up at an ICU unit when they develop sepsis. They started studies to find the cause of this protective effect that an infection with this worm seems to have.”

According to Leeuwen, the researchers discovered that a specific protein secreted by the worm was responsible for the effect. “We have already shown that the protein leads to a much better survival of mice with sepsis, confirming the protective effect seen in filaria patients. But mice are not human, Thus, SurvivX needs to show the safety and activity of the protein in humans before it can be tested as a novel therapeutic approach,” he added.

source/content: indianexpress.com (headline edited)

KARNATAKA: ARTS & CRAFTS / FASHION: Namratha Manjunath Wins ‘Miss Mysuru 2023’ Crown and First Runner-Up Bhavana Narayan

Inner Wheel Club of Mysuru Aisiri with Nandini Nagaraj Pageant Initiative and RK Universe Coorg had hosted ‘Miss Mysuru 2023’ event recently at The Viceroy Comforts in Mysuru.

‘Miss Mysuru 2023’ winner Namratha Manjunath , a medical student, first runner-up Bhavana Narayan and second runner-up Harshitha, are seen with the jury members Dr. Hemamalini Lakshman (Mrs. India Universe 2018), Prathiba, K. Kavya and Sowhardini.

source/content: starofmysore.com (headline edited)

INTERNATIONAL, NATIONAL & KARANATAKA / HEALTH & MEDICAL SERVICES : Bengaluru-based Dr Sandeep Nayak among 3 Winners of top ‘KS International Robotic Surgery Innovation Competition’ by Michigan based Foundation

Bengaluru-based robotic surgeon Dr Sandeep Nayak has been named among the three surgeons from the US and India who won top honours at the ‘KS International Robotic Surgery Innovation competition’ by Michigan-based Robotic Surgery evangelist Vattikuti Foundation.

The video entry by eminent robotic surgeon from MACS Clinic and Fortis Cancer Institute, Bengaluru was placed at the third spot for devising a novel approach for removal of thyroid tumours using minimally invasive robotic surgery.

Dr Nayak presented results of over 50 surgeries conducted over five years using this method with better patient outcomes and negligible scarring.

Robotic surgeons Dr Somashekhar SP, Aster Hospitals, Bengaluru, and Dr Aditya Kulkarni, Ruby Hall Clinic, Pune were among the top 10 vying for KS international robotic surgery award, the foundation said in a statement during the awards ceremony at Orsi Academy, Ghent, Belgium over the weekend.

“By focusing on robotic technology and surgeon education, the Vattikuti Foundation has proven the transformative power of innovative technology in revitalizing patients’ health at the hands of inventive humans,” said Raj Vattikuti, Founder, the Vattikuti Foundation.

Dr David Neal, Professor Emeritus, University of Cambridge and Oxford, Cambridge, UK; Dr Rajeev Kumar, Professor of Urology and Associate Dean (Academics), AIIMS, New Delhi; and Dr Sherry M Wren, Professor of Surgery, Stanford University, US were in the final jury that chose the top 3 from among the 141 submissions.

The video entry of Dr Adeel Khan, Washington University School of Medicine, St. Louis, demonstrating the first Robotic Liver Transplant (RLT) in the US using a deceased donor in the world was judged No 1.

The video entry of Dr Ahmed Ghazi, director of minimal invasive and robotic surgery and director of simulation training at Johns Hopkins University, US was adjudged No 2 for devising a novel patient specific simulation platform before complex robotic renal cancer surgeries.

Video submission on robot-assisted total knee transplant by Orthopaedic Surgeon Dr Suhas Masilamani, Sunshine Bone & Joint Institute and KIMS-Sunshine Hospital, Hyderabad won the people’s choice award based on rankings by surgeons from 63 countries.

Entries from procedures in 10 specialties, including urology, gynaecology, gastro-intestinal, organ transplant and head and neck, from 14 countries were received in the global competition.

source/content: daijiworld.com (headline edited)

WORLD / NATIONAL/ KARNATAKA: WORLD RECORD SPORTS : Sibling Sisters, 10-year old Ovee Malve and Ruchi Malve from Bengaluru become World’s Youngest Certified Scuba Diver Sisters

Their interest in scuba diving stemmed from those videos and they started swimming and later training for scuba diving.

A day after turning 10, Bengaluru-based Ovee Malve set a world record of becoming the youngest certified scuba diver.

With this, both Ovee and her sister Ruchi, daughters of Bangalore Mountaineering Club founder Neeraj Malve, have become the youngest certified scuba diver siblings in the world. Neeraj himself has been a scuba diver for 16 years now. Ovee achieved the feat in Puducherry at 7.18 am on October 11, becoming the youngest Professional Association of Diving Instructors-certified open water diver. 

Elated and proud, Neeraj said he understands that adventure sports are not easy, especially at a young age. He never pressured his children and ensured that they underwent proper training. The daughters were water babies since they were little and were fascinated with his scuba diving videos.

Their interest in scuba diving stemmed from those videos and they started swimming and later training for scuba diving, he said. Ovee enrolled for a junior open water diver course at Temple Adventures, Puducherry and trained under coach Shreya Mehta. 

Her sister Ruchi (14) trained under Shaurya Tarni of Dive Goa in Goa. Ruchi enrolled for the Junior Open Water Diver certification course on October 27, 2022 and received the Scuba Schools International certificate on October 30, 2022. At the age of 10 and 13, both Malve sisters have become the world’s youngest scuba diver sisters.

Previously, a Mumbai-based boy, Dwit Nandu, at age 10 set the world record around 8 am on August 25, 2023.

Both the sisters underwent two-day rigorous training which included a 200-metre nonstop swimming and floating for 10 minutes without any support. 

They studied five chapters of theory about performing underwater skills in confined waters, passed a written exam and successfully performed four dives in open water up to 18-metre depth to earn their open water diver certification.

source/content: newindianexpress.com (headline edited)

KARNATAKA: SCIENCE & TECHNOLOGY: RESEARCH / NANOENZYMES: Scientists of Indian Institute of Science (IISc) Develop Enzyme Mimetic with potential applications in Wastewater Treatment, Healthcare

The nanozyme can degrade pollutants in wastewater by oxidising them in the presence of sunlight, thereby reducing the toxicity of wastewater.

Scientists at the Materials Research Centre (MRC), Indian Institute of Science (IISc), have developed a new type of enzyme mimetic that can degrade toxic chemicals in industrial wastewater effectively in the presence of sunlight. 

Enzymes are proteins that catalyse a majority of biological reactions in living systems. However, the practical use of natural enzymes is hindered by inherent limitations such as sensitivity to denaturation (breakdown/damage), complex production procedures, high costs, and difficulties in recycling, says Subinoy Rana, Assistant Professor at MRC and corresponding author of the paper published in Nanoscale

Mass producing these enzymes is an expensive and time-consuming process. Another problem is storage – most of the natural enzymes are temperature-sensitive and require storage at cooler temperatures, often as low as -20°C. 

Nano-sized enzyme mimetics or “nanozymes” manufactured in the lab can mimic such natural enzymes and overcome these practical challenges.  

In the current study, the IISc team synthesised a platinum-containing nanozyme called NanoPtA, which can be converted into powder form for industrial use. 

When the NanoPtA comes in contact with wastewater, the benzene rings and long alkyl chains present in the molecule form multiple non-covalent interactions. Individual NanoPtA molecules connect together to form tape-like structures that start emitting light, which is the origin of its oxidising capacity. The nanozyme can then degrade pollutants present in wastewater by oxidising them in the presence of sunlight, thereby reducing the toxicity of wastewater. 

The team found that the nanozyme could degrade even small (micromolar) quantities of common effluents like phenols and dyes within ten minutes when placed under sunlight. The researchers also found that the NanoPtA complex was quite stable, lasting for up to 75 days at room temperature.  

The team believes that the nanozyme can also have applications in healthcare and could be a potentially useful diagnostic tool for neurological and neurodegenerative diseases. 

source/content: thehindu.com (headline edited)

NATIONAL & KARNATAKA: SPORTS / GOLF: Kavery Muthanna Represents India As A Golf Official At Asian Games

Mukkatira Kavery Muthanna, a resident of Mysuru, is currently serving as a member of the officiating team in the game of golf at the ongoing 19th Asian Games, which are taking place in Hangzhou, China. 

She holds a role in the Technical Rules Official team, which consists of 24 referees from various countries. The official rounds are scheduled to take place from Sept. 28 to Oct. 1 at the West Lake Golf Course in Hangzhou, featuring 121 players.

Kavery Muthanna is well-qualified, having completed the Level 3 Tournament Administrators and Referees Seminar (TARS) under the R&A. (R&A is a leading body within the world of golf and engages and supports activities to ensure it is a thriving sport for all on a global scale.) 

She has actively officiated various amateur and women’s professional golf tournaments in India, showcasing her expertise in the field. Her experience also extends to her role as a Rules Official at the 36th National Games in 2022, held in Ahmedabad.

In addition to her involvement in golf and sports officiating, Kavery Muthanna is part of the Kavery Education Trust in Virajpet and serves as its Chairperson. She is married to Mukkatira Manju Muthanna and is the daughter of Guddanda Kanthy and Nanda Ganapathy.

source/content: starofmysore.com (headline edited)

INTERNATIONAL & NATIONAL & KARNATAKA: Sudha Murty, the First Woman to get Global Indian Award by the Canada India Foundation

Renowned author, philanthropist and wife of Infosys co-founder N. R. Narayana Murty, Sudha Murty, was conferred with the Global Indian Award by the Canada India Foundation at the biggest Indo-Canadian gala here.

The Global Indian Award, which is worth $50,000, is given each year to a prominent Indian who has made a major mark in his or her chosen field.

“We are so pleased to present the Global Indian Award to Sudha Murty. She has spent her entire career paving the way for future generations to find success in whatever field they choose, and is passionate about giving back to society,” said Canada India Foundation chairman Satish Thakkar on Saturday night.

Accepting the award from Indian High Commissioner Sanjay Kumar Verma, Sudha Murty said, “It is my honour to get this award from your country.”

Thanking the Canada India Foundation (CIF) for choosing her for this award, Murthy said, “The CIF is like Krishna in the Mahabharata. Krishna is the son of Devki as well as Yashoda. Devki was his biological mother and Yashoda brought him up. You are born in India but settled here – that is Yashoda – and your mother is India. You belong to both mothers.”

Lauding the Indo-Canadian diaspora as a bridge between the two countries, she said, “You are the carriers of Indian culture in a different land. Please keep it up.”

As her husband was also given the same award in 2014, Sudha Murty said amid laughter, “There is a funny thing about this award because Narayana Murty also got it in 2014 and I got it in 2023. So we’re the first couple to get this award.”

She donated the award money to The Field Institute (University of Toronto) which is internationally renowned for strengthening collaboration, innovation, and learning in mathematics and across a broad range of disciplines.

Sudha Murty was accompanied by the parents of her son-in-law and British Prime Minister Rishi Sunak to the Toronto gala event.

source/content: daijiworld.com (headline edited)

NATIONAL & KARNATAKA: SPORTS :Asian Games 2023: Karnataka’s Aditi Ashok Wins Historic Silver In Golf For India

Indian shooters clinch gold and silver

Karnataka’s Golf star Aditi Ashok today bagged a historic Silver medal for India at the Asian Games 2023 after missing the Gold medal in Hangzhou.

Aditi finished the four-round event with a score of 17 under 271 to take the second prize. Thailand’s Arpichaya Yubol leapfrogged the Indian to take the Gold medal home.

Aditi was in the Gold medal contention on the final day of the contest as she had a 22-under score after three rounds. She was seven shots clear of Yubol but had a poor day with 5 over on the final day. However, Aditi Ashok is the first Indian woman to win a medal in golf at the Asiad.

Indian shooters won two medals, clinching gold and silver in men’s and women’s trap events. The Indian men’s team comprising of Kynan Chenai, Zoravar Singh Sandhu and Prithviraj Tondaiman has claimed gold in the Trap event on Sunday, October 1 to continue India’s fantastic run in shooting so far in the Asian Games 2023.

India were able to fend off competition from Kuwait and China to secure the top spot on the podium to take the tally in shooting to 21 medals with 7 gold, 9 silver and 5 bronze. In addition to the gold medal win Chenai and Sandhu have also qualified for the individual final as well.

The Indian trio secured 361 points in total as compared to Kuwait’s 352 and China’s 346.

Earlier in the day, India had won the silver medal in the women’s trap team event in shooting. The trio of Rajeshwari Kumari, Manisha Keer and Preeti Rajak finished second with 337 points, behind China.

So far (till 1.30 pm on Oct. 1), India stands 4th in the medal tally with 41 medals including 11 gold, 16 silver and 14 bronze.

Yesterday (Sept. 30), Rohan Bopanna and Rutuja Bhosale won gold in the Mixed Doubles after winning the third set tie-breaker against Chinese Taipei to secure India’s second medal in tennis after Ramkumar Ramanathan and Saketh Myneni’s silver in Men’s Doubles.

The Indian men’s team beat Pakistan men’s squash team event to give India its 10th gold in this Asian Games.

Sarabjot Singh and Divya Thadigol topped the qualification in the 10m Air Pistol Mixed Team but settled for a silver in the final, going down 14-16 to China.

In the men’s 10000m, Kartik Kumar and Gulveer Singh won silver and bronze, respectively.

source/content: starofmysore.com (headline edited)

INTERNATIONAL & NATIONAL & KARNATAKA: SPORTS / CRICKET: Siddaramaiah felicitates Gold Medal-Winning Indian Blind Women’s Cricket Team

 Chief Minister Siddaramaiah felicitated the members of the Indian blind women’s cricket team and the blind men’s cricket team from Karnataka at the Home Office Krishna on Friday.

The Indian blindwomen’s cricket team won the gold medal, and the blind men’s cricket team won silver medal in the IBSA World Cricket Tournament (Cricket for Bind) .

The Chief Minister felicitated the captain of the Indian blind women’s cricket team Varsha.U and team players, Deepika, Gangavva, and Prakash J, Sunil Kumar, Basappa Voddgol of the men’s team from Karnataka.

The visually challenged Indian women’s cricket team in August scripted history by winning a gold medal beatingAustraliaby nine wickets at the IBSA World Games.

The team of medal winning players led by Govinda Raju, the president of the Karnataka State Olympic Organisation and political secretary to the Chief Minister, met the Chief Minister and presented their demands.

The Chief Minister responded positively and assured tohold a separate discussion with Govindaraju and to takeappropriate decisions to fulfill their demands.

Chief Minister Siddaramaiah interacted with the players and asked them interesting questions about the training the players get, how they recognize a ball, how many matches have they played, etc..

The Chief Minister’s Political Adviser Naseer Ahmed, Life President of Cricket Association for Blind India Mahantesh, CABI President Boosagowda and representatives of Samarthanam Trust were also present.

source/content: daijiworld.com (headline edited)

KARNATAKA : GREEN ENERGY: Bengaluru start-up offers a ‘ZEN’ Solution to Fire Risks and Low Life of EV Batteries

EMO Energy has developed a platform which combines software, hardware, cloud, and intelligence to improve safety and life of batteries which can be used across high energy and high-power applications.

The adoption of electric vehicles has been on the rise in India. As per data from the Ministry of Heavy Industries, more than 27 lakh electric vehicles have been registered in the country as of July 2023 with Karnataka seeing the third highest number of registrations.

However, incidents of electric vehicles and battery swapping stations catching fire have been a cause of concern to consumers and potential users.

“Over the last year, more than 200 vehicles caught fire in India, primarily due to overcharging and overheating or short circuits. Batteries are not designed to withstand the abuse, and in the scenario where a cell bursts, the whole vehicle catches fire due to improper mitigation,” says Mohammed Shoeb Ali, co-founder and managing partner at Transition VC, an energy transition-focused venture capital fund.

Bengaluru-based startup EMO Energy may have a solution for it. Founded by Sheetanshu Tyagi and Rahul Patel, EMO Energy has developed a platform that combines software, hardware, cloud, and intelligence to improve the safety and life of batteries. Called ZEN, the platform targets battery usage in high-energy and high-power applications from electric two wheelers to agriculture to mining and construction.

Safety and life

“We realised that all these applications have the same kind of issues. One is safety,” says Mr. Tyagi.

“You are operating in high temperature, and you want batteries that charge fast, pull more power and are smaller in size. And then there’s the concern of life. While vehicles have a life of seven to eight years, every two to three years you are losing a battery,” he adds.

The team put together their heads to understand how they could enhance the performance of batteries and solve the existing problems around it.

“Initially we thought we would build a software system and take it to different original equipment manufacturers (OEM) and battery companies who could use it to improve the life and safety of their batteries,” remembers Mr. Tyagi.

But then they realized the existing hardware in the country wasn’t strong enough for it. Most systems where Chinese derivatives that were basic and poor in technology.

“China spends time in developing batteries for small scooters. India just scaled that to big scooters,” Tyagi says.

According to Mr Ali from Transition VC who is also an investor at EMO Energy there is a massive demand-supply gap between the battery pack manufacturers and OEMs. He notes that the industry lacks companies that give warranties for the pack as many of them import them from China.

“Customers face range anxiety, battery degradation and warranty issues due to lack of quality battery packs, and this becomes even worse in temperatures greater than 40 degrees Celsius,” he says.

Intelligent battery system

The team understood that to ensure the performance safety and battery life at a cost people expected, they have to build everything around the battery system from scratch. The startup, therefore, bought specific cells and built a mechanical system around it.

EMO Energy developed a fluid in which the cells would be immersed. The fluid transmits heat more efficiently, absorbs energy in case of a cell blast and prevents electricity transmission.

Mr. Tyagi notes just leaving the cells in the fluid does not serve the purpose. The fluid has to keep circulating in a very specific manner. It also needs to be ensured that the fluid rejects heat to the system and in case of a cell blasting open, it has to absorb the energy quickly and prevent it from reaching other cells. So, taking it one step further the company built a layer of intelligence around the fluid.

“We have sensors that monitor every single temperature and voltage across the system. That allows us to put more power, remove more heat and maintain temperature even if you are operating at higher temperature, all at an affordable cost. You can use the software to understand what is happening at a cell level, improve performance, predict safety issues and diagnose and fix them. All of these except the cells have been developed in-house,” Mr. Tyagi explains.

According to him, there are three layers to the software. One is the several sensors inside the battery. They communicate to a Battery Management System and through the cloud some of it gets transmitted to an app which the user can see.

“There is also another layer we offer to the fleet operators where they can see all drivers in a very detailed a map. The driver’s driving patterns and habits and the way they charge can drastically change a vehicle’s range. Our technology would allow to rank performances based on battery health,” he explains.

The system can be connected to a standardized three pin socket which would give 80 odd kilometres after 30 minutes of charging.

According to the company, about 300 systems have been sold so far. It claims to have orders to the tune of 40,000. “We are scaling up to 10,000 now, we are still in the process of becoming bigger,” Mr. Tyagi says.

Net zero goals

Depending on the quality of batteries, Lithium-ion batteries cost between ₹12,000 to above ₹20,000 per kWh in India today. EMO systems comes to around ₹17,000 per kWh.

“The objective for us is to maintain the performance-to-cost ratio. If somebody is looking at scale in the ₹15,000+ segment, we offer the highest lifecycle there. We provide more than 2,000 cycles for any kind of cell chemistry,” Mr. Tyagi notes.

With its direct thermal management system and in-house battery management system coupled with artificial intelligence and machine learning capabilities, Mr. Ali believes EMO Energy can not only offer customers the best product features at optimal prices but also help significantly reduce battery pack imports from China.

“EMO’s modular design approach enables them to scale them across multiple mobility applications such as two-wheeler, three-wheeler, and four-wheeler passenger and commercial vehicles and also across sectors such as energy storage for residential and commercial applications,” he notes.

The start-up claims to have done business of more than ₹5 crores now with a turnover of more than ₹40 lakhs every month. The company currently works with 10 clients and holds 16 patents.

Mr. Tyagi notes that the company aligns its plans with a net zero goal.

“We think in terms of building a battery system, using our software to improve its health, maximise its usage in vehicles, at the end of it put it in secondary storage in home applications, maximise the use there, then recycle it, take the cell material, work with cell companies to put that in their cells, then put that back in the battery,” he explains.

“That’s a very long chain and we are at step-1 today.”

source/content: thehindu.com (headline edited)