Category: Inventions, Innovations

KARNATAKA: HEALTH & MEDICAL SERVICES / INNOVATION: Indian Institute of Science (IISc) Scientists Develop Gold-Coated Vesicles to Fight Tuberculosis (TB)

The spherical vesicles, which can be delivered to immune cells, are expected to potentially trigger an immune response.

To combat tuberculosis, researchers at the Indian Institute of Science (IISc) have designed a new method under which a vaccine candidate for the disease can be delivered by making use of Outer Membrane Vesicles (OMVs). These spherical vesicles, which can be delivered to immune cells, are secreted by bacteria coated on gold nanoparticles. The deliverance is expected to potentially trigger an immune response to offer protection against TB.

Across the world, TB, which is caused by a bacterium called Mycobacterium tuberculosis, claims the lives of over a million people every year. Currently, BCG is the only effective vaccine against TB. It contains a weakened form of the disease-causing bacterium, which when injected into the bloodstream, produces antibodies which can help fight the disease.

However, the scientists have said that the BCG vaccine does not protect adolescents and adults as effectively as it does children. Prompted by this, Rachit Agarwal, Assistant Professor at the Centre for BioSystems Science and Engineering (BSSE), IISc, and his group worked on developing a potential subunit vaccine candidate that contains only parts of the infectious bacterium to stimulate an immune response.

Although other scientists had developed subunit vaccines based on a handful of proteins from the disease-causing bacteria earlier, they had not been effective in the treatment. Agarwal’s group decided to take a slightly varied approach and made use of OMVs — which are spherical membrane-bound particles released by some bacteria, and contain an assortment of proteins and lipids which could induce an immune response against the pathogen.

“They’re safer compared to a live bacterium, and since they are membrane-derived, they contain all kinds of antigens,” explained Agarwal, the senior author of the paper published in  Biomaterials Advances. The researchers further explained that while subunit vaccines typically only contain a limited number of antigens — bacterial proteins that can elicit an immune response in the host, the OMVs contain a variety of antigens, which can induce a better immune response.

“Mycobacterium-derived OMVs are usually unstable and come in different sizes, making them unsuitable for vaccine applications. But the OMVs coated on gold nanoparticles (OMV-AuNPs) by the IISc team were found to be uniform in size and stable. The researchers also found that human immune cells showed a higher uptake of OMV-AuNPs (gold nanoparticles) than of OMVs or gold nanoparticles alone”, said an IISc press release. 

According to Avijit Goswami, a former postdoctoral fellow at BSSE and one of the first authors of the study, the most challenging part was the production and scaling up of OMVs as it was a complex process. “To synthesise OMV-AuNPs, the OMVs and the gold nanoparticles are forced together through a 100 nm filter. The OMVs break up in the process and encapsulate the gold nanoparticles,” explained Edna George, a former postdoctoral fellow at BSSE, and co-first author of the study.

During this study, the immune cells, which were cultured in the lab, were treated with OMVs derived from a related bacterial species which does not cause disease in humans, called as Mycobacterium smegmatis. Furthering their research, the team plans to develop gold-coated OMVs derived directly from Mycobacterium tuberculosis. They will then test the same on animal models and carry the results forward for clinical applications.

“Such efforts could open up new avenues for the development of vaccines for other bacterial diseases as well”, the release said.

source/content: thehindu.com (headline edited)

KARNATAKA: SCIENCE, TECHNOLOGY & HEALTH SERVICES: OPHTHALMOLOGY: SAP, CleaVision to Deploy Deep Tech to minimise Blindness in Premature Babies

The solution is currently being piloted at Narayana Nethralaya Eye Institute in Bengaluru.

The power of machine learning and data analytics can be explored to reduce blindness that occurs as a result of Retinopathy of Prematurity, a condition where abnormal growth of blood vessels inside the eyes of pre-term babies can cause bleeding, scarring and retinal detachment, as per SAP.

SAP and CleaVision, a social venture, on Thursday announced an initiative aimed at reducing the risk of preventable blindness as a result of Retinopathy of Prematurity (ROP) in pre-term babies.

A solution driven by machine learning and data analytics would help doctors to arrive at a more accurate diagnosis while treating such babies, said SAP in a statement. The solution is currently being piloted at Narayana Nethralaya Eye Institute in Bengaluru.

“We are piloting the software through the KIDROP (Karnataka Internet Assisted Diagnosis of ROP) programme, which performs up to 2,500 imaging sessions each month from 135 neonatal units across Karnataka,” said Dr. Anand Vinekar, Head, Paediatric Retina Department at Narayana Nethralaya Eye Institute.

Automating the screening process

Explaining the process, the company said, the CleaVision solution would integrate image data processing with SAP Business Technology Platform, SAP AI Platform, and SAP Analytics Cloud to automate the identification of retina and blood vessel features and to make a recommendation on plus disease – a severe manifestation of ROP in premature babies.

The screening data would then be served to hospitals and could be reviewed in the KIDROP telemedicine network.

source/content: thehindu.com (headline edited)

NATIONAL: INTERNATIONAL COLLABORATION in AI : Australia’s AICRAFT and Bengaluru’s VALDEL Inks MoU on AI in Aerospace

One more memorandum of understanding was inked between India and Australia to use artificial intelligence and machine learning in aerospace, on the final day of the Bengaluru Space Expo (BSX), 2022. 

The MoU was signed between Bengaluru-based aerospace company Valdel Advanced Technologies and Australian artificial intelligence company AICRAFT. The MoU, which was signed in the presence of Indian Space Research Organisation (ISRO) scientific secretary Shantanu Bhatawdekar and Australian Space Agency head Enrico Palermo, will work towards using the AI capabilities of AICRAFT to help Valdel with simulation and manufacturing capabilities through the use of advanced AI and machine learning.

“We are pleased that Australian industry has continued to explore tangible space collaboration with India over the past few days. Both parties have agreed to utilise AICRAFT’s advanced artificial intelligence and machine learning capability and products to support Valdel’s modelling, simulation and manufacturing capabilities. Valdel’s facilities will also be used to test AICRAFT’s systems and platforms,” said Sarah Kirlew, Consul General for South India, who announced the MoU on Wednesday.

On Monday, as many as six MoUs were signed between several Australian and Indian companies, including two Bengaluru-based companies. In addition to this, Australia’s Space Machines Company, an aerospace company, opened a new research and development office in Bengaluru.

source/content: newindianexpress.com (edited)

COVID-19: HEALTH & MEDICAL SCIENCES / HEALTH & TECHNOLOGY: Indian Institute of Science (IISc) Bangalore Researchers Develop Covid Doppelganger

When the pandemic hit, IISc professor Soma Das and his team began working on a VLP for SARS-CoV-2.

 The Indian Institute of Science (IISc) has developed and tested a novel virus-like particle (VLP) – a non-infectious nanoscale molecule that resembles and behaves like the virus but does not contain its native genetic material – in a study published in Microbiology Spectrum.

When the pandemic hit, IISc professor Soma Das and his team began working on a VLP for SARS-CoV-2. They artificially synthesised a VLP with all four structural proteins – spike, envelope, membrane and nucleocapsid. “The main challenge was to express all four structural proteins together,” said Harsha Raheja, PhD student at MCB.

Such VLPs have several uses and can also potentially be developed into a vaccine candidate that can trigger an immune response in our bodies, Das said, adding that they can also be used to reduce the time taken to screen drugs that can fight the virus. When the team injected a high dose of VLPs into mice in the lab, it did not affect the liver, lung, or kidney tissues.

Testing immune response
To test its immune response, they gave one primary shot and two booster shots to mice models with a gap of 15 days, after which they found a large number of antibodies generated in the blood serum of the mice. These antibodies were also capable of neutralising the live virus, the team found. “This means that they are protecting the animals,” explained Raheja.

The researchers have applied for a patent for their VLP and hope to develop it into a vaccine candidate. They also plan to study the effect of the VLP on other animal models (using the expertise of SG Ramachandra, one of the inventors), and eventually humans. Raheja said they have also developed VLPs that might be able to offer protection against the more recent variants, like Omicron and other sub-lineages.

source/content: newindianexpress.com (headline edited)

NATIONAL: KARNATAKA / BUSINESS & ECONOMY, : 3 Bengaluru Startups Win at Conquest a BITS Pilani Students Run Event – Green Tiger Mobility, Daffodil Health and StreamMoney

Green Tiger Mobility, the cleantech firm, and Daffodil Health, a healthcare startup, won in the Pan India Track, where participants were invited from across the country.

Of the 15 startups, shortlisted from over 1,500 applications, four have been selected to receive an equity-less grant of Rs 30 lakh each. Of these, three are from Bengaluru. Winners were chosen based on three categories or tracks — Pan India, BITSian and Web3.0. 

Green Tiger Mobility, the cleantech firm, and Daffodil Health, a healthcare startup, won in the Pan India Track, where participants were invited from across the country.

Green Tiger is working on developing a hybrid vehicle, while Daffodil Health is a behavioural healthcare platform aimed at children.The latter aims at giving parent-mediated therapy to children with behavioural and developmental disorders like autism, ADHD, dyslexia and others.

Conquest, run by around 30 engineering students from BITS Pilani’s Centre of Entrepreneurial Leadership, is the first and largest student-run startup accelerator, hosting programmes every year to help startups get funding and mentors. 

The Demo Day for the 18th edition of the accelerator programme was held in Bengaluru on Sunday, with 15 startups shortlisted to pitch their ideas to a panel of investors, industry leaders and others. Another Bengaluru-based company StreamMoney won in the Web3.0 Track, where the focus is on startups developing or utilising technology related to Web3.0. StreamMoney focuses on the ability to transfer conditional ownership of non-fungible tokens (NFTs). 

The startup is working towards making a utility protocol, allowing NFT owners to rent out or allow ticketing or subscriptions of their NFTs. This allows owners to add in a utility contract with their NFTs that allows access to their tokens for a limited period of time.

Green Tiger Mobility, the cleantech firm, and Daffodil Health, a healthcare startup, won in the Pan India Track, where participants were invited from across the country.

 A clean technology firm, focusing on building hybrid cars that allow you to switch between electric and internal combustion engines at the switch of a button, was one of the three Bengaluru startups that won big at BITS Pilani’s Conquest.

Of the 15 startups, shortlisted from over 1,500 applications, four have been selected to receive an equity-less grant of Rs 30 lakh each. Of these, three are from Bengaluru. Winners were chosen based on three categories or tracks — Pan India, BITSian and Web3.0. 

Green Tiger Mobility, the cleantech firm, and Daffodil Health, a healthcare startup, won in the Pan India Track, where participants were invited from across the country. Green Tiger is working on developing a hybrid vehicle, while Daffodil Health is a behavioural healthcare platform aimed at children.

The latter aims at giving parent-mediated therapy to children with behavioural and developmental disorders like autism, ADHD, dyslexia and others. Conquest, run by around 30 engineering students from BITS Pilani’s Centre of Entrepreneurial Leadership, is the first and largest student-run startup accelerator, hosting programmes every year to help startups get funding and mentors. 

The Demo Day for the 18th edition of the accelerator programme was held in Bengaluru on Sunday, with 15 startups shortlisted to pitch their ideas to a panel of investors, industry leaders and others.

Another Bengaluru-based company StreamMoney won in the Web3.0 Track, where the focus is on startups developing or utilising technology related to Web3.0. StreamMoney focuses on the ability to transfer conditional ownership of non-fungible tokens (NFTs). 

The startup is working towards making a utility protocol, allowing NFT owners to rent out or allow ticketing or subscriptions of their NFTs. This allows owners to add in a utility contract with their NFTs that allows access to their tokens for a limited period of time.

source/content: newindianexpress.com (headline edited)

KARNATAKA: SCIENCE & TECHNOLOGY / INNOVATION: Mysuru’s Vidyavardhaka College of Engineering (VVCE) Students Develop an ‘Automated Stick for the Visually Challenged’

Four students from Vidyavardhaka College of Engineering (VVCE), Mysuru, have developed an automated stick as a supportive device for the visually challenged.

Constant worry about potholes and obstacles affects the confidence of the visually impaired when they step out of their home. The stick helps them traverse safely, identifying potholes and hurdles while moving in crowded places, according to the students.

The stick developed by the students uses ultrasonic sensors for obstacle detection and pothole detection for ensuring timely alerts to the visually challenged person.

Smrithi Baliga, a third-year Electronics and Communications Engineering student at VVCE, was worried seeing visually-challenged persons facing difficulties while crossing roads.

Teaming up with enthusiastic classmates Sapna H.M., Shreyas N., and Yogesh Gowda V., Ms. Smrithi came up with the idea of developing the stick. The Internet of Things (IoT)-based stick with an obstacle and pothole detection system using ultrasonic sensors was developed with guidance from Chandrashekar M. Patil, professor and Head, Department of ECE, and Girijamba D.L., assistant professor.

B. Sadashivegowda, principal, VVCE, said: “We are proud of our students for taking up the project. In recent times, technology has helped improve healthcare across the world. Through this project, our students have proven how technology could be used to fight visual impairment. The automated stick helps visually-impaired individuals move freely with confidence.”

The students have proposed to bring in some improvements to their product. Voice output via Bluetooth; upgrade of pothole detection from ultrasonic sensors to image-processing technique; LDR to sense lighting conditions; RF remote to locate the stick itself are among the additions, a note from the college said.

source/contents: thehindu.com (headline edited)

KARNATAKA: SCIENCE & TECHNOLOGY, EDUCATION: Srinivas Institute of Technology (SIT) Students Receive ‘Best Project of the Year Award’ for the Project’ Energy Generation using Fly-Wheel & Magnet’. Simultaneously ‘Robotic Arm Installed Fruit Plucking UAV based on AI’ was Awarded the ‘Best Project Of The Year’ under Seminar Category

The 45th series of state-level ‘Student Project Program’ was conducted by KSCST, Bengaluru, in association with VTU, Belagavi on August 12 and 13 at VTU.

In this project exhibition, project titled ‘Energy generation using fly-wheel and magnet; was awarded the ‘Best Project Of The Year’ under the project exhibition category.

This project was carried out by the students- Chirag G Poojary, Karthik C, Sajith and Vijetha K Naik of department of Electrical and Electronics Engineering, under the guidance of professor Lokesha B.

Also, the project titled ‘Robotic Arm Installed Fruit Plucking UAV based on AI’ was awarded the ‘Best Project Of The Year’ under seminar category. This project was carried out by the students- Navaneeth Soni, Naveen Kumar, Nithin Kumar and Vardhaman Ravindra Vasavade of department of Aeronautical Engineering, under the guidance of professor Srinidhi Kukkila.

Dr Karisiddappa, vice-chancellor of VTU presented the awards.

There were 332 projects for the exhibition. Dr CA A Raghavendra Rao, president and Dr A Srinivas Rao, vice-president of Srinivas group of institutions have appreciated the efforts by the students and also congratulated them for winning the awards.

Dr Shrinivasa Mayya D, principal and the heads of the departments have also complemented the students for their outstanding performance in the programme and receiving the awards.

source/content: daijiworld.com (headline edited)

NATIONAL: DEFENCE, SCIENCE & TECHNOLOGY, AVIATION: Hindustan Aeronautics Ltd (HAL) Developing AI-Driven Long-Endurance Drone for Strategic Visions and Vigil over Long Borders

State-run aerospace behemoth Hindustan Aeronautics Ltd (HAL) is working on an AI-driven multi-role, advanced and long-endurance drone for strategic missions in high-altitude areas including along the frontiers with China, people familiar with the development said on Sunday.

The rotary-wing drone will have the capability to carry a load of 40 kgs, including missiles and sensors, and it is being developed considering the requirement of the armed forces to keep a strong vigil over the mountainous areas along the Line of Actual Control (LAC), they said.

The HAL has set a target of conducting the maiden test-flying of the unmanned aerial vehicle (UAV) by the middle of next year and plans to produce 60 such platforms in the first phase of the project, the people in the know told PTI.

They said the operating system of the long-endurance drone will feature applications of Artificial Intelligence and the armed forces will be able to use it for multiple purposes including transporting essential supplies.

source/content: newindianexpress.com (headline edited)

NATIONAL: KARNATAKA: HEALTH & MEDICAL SCIENCES, VACCINE: RT-PCR Detection Kit for Human Monkeypox Virus Developed by NeoDv Biotech Labs Released

Company obtained manufacturing licence from CDSCO and is awaiting clinical validation of kit, which uses gold-standard RT-PCR method.

A human monkeypox virus (MPXV) multiplex RT-PCR detection kit was released by Minister for IT and BT and Science and Technology C.N. Ashwath Narayan on Friday.

Developed by NeoDx Biotech Labs, the MPXV kit is designed for specific detection of the Central African (Congo Basin) and West African Monkeypox virus clades. The kit uses gold-standard Taqman chemistry-based RT-PCR method.

The company has obtained the manufacturing test licence from Central Drugs Standard Control Organisation (CDSCO), under Directorate General of Health Services, Ministry of Health and Family Welfare, Government of India, and is waiting for clinical validation of the kit, according to a press release.

The kit was released on the occasion of the foundation-laying ceremony for the “Research and Training Unit for Rare Diseases” held at the Centre for Human Genetics (CHG) in Bengaluru.

The CHG, under the guidance of the founding Director, Professor H. Sharat Chandra, for the past 20 years, has been providing high quality genetic services to patients with rare diseases from all over Karnataka and other states, the release said.

Meenakshi Bhat, Associate Director at CHG said nearly 35,000 families with genetic disorders have been diagnosed and counselled in the past 15 years. “The genetic laboratories at CHG provide diagnostic testing in around 5,000 patients per year. The majority of these patients are from government hospitals in Karnataka and these services are provided free to BPL and other eligible patient families and at cost to others,” she said.

The Research and Training Unit for Rare Diseases is an extension of the present CHG building. This 40,000 sq. ft extension will have three floors in which comprehensive genetic counselling facilities for around 2,500 families with rare disorders will be evaluated annually, she said.

content/source: thehindu.com (headline edited)

NATIONAL: BUSINESS & ECONOMY/ MINING, DRONES: Tata Steel Signs MoU with Bengaluru Start-up Aarav Unmanned Systems (AUS) for Drone-based Mining Solutions, Analytics & Geo-Technical Mapping

Tata Steel will also work jointly with AUS to provide exclusive drone-based solutions, including mine analytics and geo-technical mapping, to Tata Steel group companies.

Domestic giant Tata Steel on Wednesday said it has inked a pact with a Bengaluru-based startup for drone-based mining solutions for effective mine management.

The primary goal of this collaboration is to jointly develop and offer sustainable and end-to-end integrated solutions that will focus on efficiency, safety, and productivity of open cast mining operations.

“Tata Steel has signed a Memorandum of Understanding (MoU) with Aarav Unmanned Systems (AUS), a Bangaluru-based startup, providing end-to-end drone solutions… for effective mine management,” the company said in a statement.

Tata Steel will also work jointly with AUS to provide exclusive drone-based solutions, including mine analytics and geo-technical mapping, to Tata Steel group companies across mining locations in India, it said.

On the partnership, D B Sundara Ramam, vice president, Raw Materials, Tata Steel, said: Drone survey enabled digitalisation and other technology will assist in gathering impactful and actionable insights. We see enormous potential in redefining core mining processes such as exploration and mine planning using drone data and adequate analytics.

source/content: business-standard.com (headline edited)