NATIONAL: KARNATAKA: SCIENCE & TECHNOLOGLY / VACCINES : IISc Develops Heat-Tolerant Covid-19 Vaccine

A team of scientists has completed pre-clinical trials and is now gearing up for human testing .

India could soon have a new vaccine for the mutating COVID-19 virus to keep the virus at bay. Scientists at the Indian Institute of Science (IISc) have been working on developing a heat-tolerant vaccine that can offer protection against different strains of SARS-CoV-2 which includes both current and future variants. The team has completed pre-clinical trials and is gearing up for the human testing of the vaccine candidate. 

According to scientists the evolving nature of the virus and different mutations, they are not sure if the current vaccines can be helpful. Raghavan Varadarajan, Professor at the Molecular Biophysics Unit (MBU) has been leading this research project in collaboration with Mynvax, a startup since the beginning of the pandemic. 

After analysing various proteins found in the virus, researchers selected two parts of SARS-CoV-2’s spike protein – the S2 subunit and the Receptor Binding Domain (RBD) – for the new vaccine. The S2 subunit is highly conserved – it mutates much less than the S1 subunit, which is the target of most current vaccines. Scientists have also known that the RBD can provoke a strong immune response in the host. The team created a hybrid protein called RS2 by combining these two components, read a statement released by IISc.  

The researchers used mammalian cell lines to study the expression of the hybrid protein. “The protein showed very high levels of expression, and initially I thought that the experiment was not working properly,” said Nidhi Mittal, PhD student at MBU and first author of the study. Further research by Mittal showed that this protein potentially be produced in large quantities.    

The team then tested the effects of the protein in both mice and hamster models. They found that the hybrid protein triggered a strong immune response and provided better protection when compared to vaccines containing the whole spike protein.  

Varadarajan told TNIE that RS2 has better coverage compared to other vaccines. This could be India’s first homegrown vaccine for the JB.1 variant and others as Covaxin developed for the mutation has become inactive. “Post clinical trials the vaccine can be administered to everyone, starting with healthy human bodies. So far in our animal testing we have not seen any side effects but will have to wait for results on humans,” added Varadarajan.

The RS2 antigen can also be stored at room temperature for a month without the need for cold storage, unlike many vaccines in the market which require mandatory cold storage. This would make the distribution and storage of these vaccine candidates much more economical.  

Varadarajan said the vaccine candidate can be tailored to incorporate the RBD region of any new variant of SARS-CoV-2 that might emerge. Its high levels of expression and stability at room temperature can greatly reduce production and distribution costs, making it well-suited for combating COVID-19. “If need be, the vaccine can also be updated as and when the mutation develops over the years,” he added. 

source/content: newindianexpess.com (headline edited0

INTERNATIONAL: KARNATAKA: DOCTORS: NRI Forum Karnataka felicitates Indian-origin American Doctors at Manipal, Udupi

 American Doctors who are of Indian origin were felicitated by NRI Forum Karnataka on Saturday January 6 at Rajathaadri, Manipal.

Dr Sampath Shivangi, founding member Association of Physicians of India, Dr Dayanand Nayak, Dr Geetha Nayak, cancer specialist, Dr Anupama Bhat, Dr Ramesh Gowda, Dr Udaya Shivangi, convener, Subramanya Bhat, Dr Rajeshwari, Dr Shantha Moorthi, Dr Sujatha Moorthi, Dr Ramdas were felicitated on the occasion.

Addressing the gathering, Dr Vidyakumari, deputy commissioner of Udupi district, said, “Today we are in the times of globalisation. America once which was very distant is now very near because of globalisation. Non-Resident Indian Forum, Karnataka, has helped Indian-origin doctors in America. It has quickly responded and helped doctors during Ukraine war and other crisis. When I was the zilla panchayat CEO in Tumakuru, when there was need for oxygen cylinders, foreign ambassadors have supplied in more quantity. They have helped a lot during the COVID pandemic.”

Dr Sampath Shivangi, thanking the gathered said, “Earlier, we were called Asian Americans and now we are called Indian Americans. This is one of the achievements we have made. We always want to help our motherland.”

Dr Dayanand Nayak said, “No other Indians have done the work Dr Arathi Krishna, the deputy chairman of the NRI Forum Karnataka has done. We are not only immigrants but also sub-Indians. No doctors from other countries receive respect as Indian doctors get in America. Dr Sampath, Dr Uday and Dr Subramanyam Bhat have contributed a lot.”

The event began with a prayer by Sachin. Dignitaries and all the doctors lighted the lamp.

Dr Arathi Krishna welcomed the gathering. Lakshmamma, working secretary of NRI Forum Karnataka proposed the vote of thanks. M A Gafoor, senior Udupi Congress leader, presided over the event.

Mamatha Devi G S, additional deputy commissioner of Udupi and others were present.

source/content: daijiworld.com (headline edited)

INTERNATIONAL / NATIONAL/ KARNATAKA: GREEN-ENVIRONMENT / SPORTS : Bengaluru’s Ultra-Marathoner Aakash Nambiar runs 104Km barefoot in Dubai to raise ‘Awareness for Climate Change’

Aakash Nambiar’s initiative was inspired by the momentum generated by COP28, the climate change conference held earlier in December.

Aakash Nambiar, a 34-year-old ultra-marathoner from Bengaluru, took to the streets of Dubai barefoot, covering a staggering 104Km in just over 17 hours and 20 minutes. Known as ‘Barefoot Mallu’ on Instagram, Nambiar’s feat was not just a test of physical stamina but also a call to action against climate change.

Starting his journey at the break of dawn from Love Lake in Al Qudra, Nambiar traversed some of Dubai’s most iconic landmarks, including the Palm Jumeirah, Burj Al Arab, Kite Beach, Jumeirah Beach, La Mer Beach, Etihad Museum, and the Museum of the Future. His final destination was the towering Burj Khalifa, which he reached by midnight. Throughout this extraordinary marathon, Nambiar ran without shoes, braving the hot Middle Eastern terrain, save for the last few stretches at night.

Nambiar’s initiative was inspired by the momentum generated by COP28, the climate change conference held earlier in December. Through his run, he aimed to engage with community members, discussing the collective effort needed to combat climate change. His message was clear: “WE ARE RUNNING OUT OF TIME” to act on this global issue.

“A 100KM inside Dubai, the city of skyscrapers!! The run started after the sun rise from Love, Lake to finish at the tallest building in the world Burj Khalifa covering Palm Jumeirah, Burj Al Arab, Kite Beach, Jumeirah Beach, La Mer beach, Etihad museum and Museum of future with a total of ~ 104KMs,” Nambiar wrote.

As reported by Khaleej Times, Nambiar expressed that running through the streets and meeting people made him feel alive and provided a powerful platform to spread his message on environmental conservation.

source/content: indiatoday.in (headline edited)

INTERNATIONAL / KARNATAKA: Bengaluru girl Veruschka Pandey showcases her skills at UN summit

Further, she stated that it is our responsibility to save people from untimely death by educating them about CPR.

A tenth grader from Bengaluru showcased her skill at the 1-Million 1-Billion (1M1B) summit held at the United Nations recently.

Veruschka Pandey, a youth changemaker from The International School, Bengaluru participated in the 1M1B Activate Impact Youth Summit held at the United Nations. It was hosted by the 1M1B Foundation on November 30 in New York. She presented her project Surya Nayak, which showcased her contribution to the implementation of Sustainable Development Goals (SDGs) in India. 

Veruschka has been working on giving CPR training to ASHA workers, bus drivers, factory workers and security personnel in Bengaluru and other parts of Karnataka. She has been creating awareness, spreading information and training people.

“I not only want to create awareness but a mass movement among health workers and the Indian youth to achieve the SDGs by 2030,” she said at the summit, adding that our hearts are like vessels that have space for empathy, love and life. Further, she stated that it is our responsibility to save people from untimely death by educating them about CPR. 

Her thoughts and works were also showcased through a documentary ‘Heart is a Vessel’ at the UN, followed by a panel discussion that included her mentor Manav Subodh and Amit Madheshiya, an award-winning movie maker at the Cannes Film Festival. A documentary on Veruschka by Madheshiva was also screened at the event. 

PR/ Ambassador Ruchira Kamboj met the youth changemaker at the Permanent Mission of India, where she engaged on a broad spectrum of issues, including Agenda 2030 and SDG implementation in India.

source/content: newindianexpress.com (headline edited)

NATIONAL: INVESTMENTS IN MEDICAL & HEALTH SERVICES: Philips Launches Innovation Campus in Bengaluru; gen AI provides more Opportunities, says CEO

The company has over 9,000 employees in India, and of these 5,000 employees in Bengaluru will be working on innovative health technologies. The company employs over 70,700 employees globally.

Generative AI (Artificial Intelligence) provides a lot of opportunities, and it is the next wave of new technology that can help solve the problems of customers, said Roy Jakobs, CEO of Royal Philips.

The company launched its new innovation campus in Bengaluru that can accommodate 5,000 employees. Speaking on the sidelines of the launch in the city on Thursday, Jakobs said if you look at healthcare, our customers are asking how we can serve more patients.

“So, we are looking at how technology can help them process more patients,” he said, explaining the significant role that AI plays in innovation.

The company has over 9,000 employees in India, and of these 5,000 employees in Bengaluru will be working on innovative health technologies. The company employs over 70,700 employees globally.

It also has a Healthcare Innovation Centre in Pune, Global Business Services in Chennai, and commercial teams in Gurugram.

For the Netherlands-headquartered Philips, India plays a significant role and it is a major hub for innovation.

“Philips has been innovating for more than 130 years and started doing business in India some 92 years ago. In the last 27 years, the Philips Innovation Campus in Bengaluru has grown to represent almost all our business categories and supporting roles,” the CEO said.

 “In India, we not only want to speed up access to care but also locally develop and contribute to solutions for the rest of the world,” he added.

Last year, with an investment of Rs 400 crore under the PLI scheme, the company’s healthcare innovation centre in Chakan, Pune, started manufacturing radio frequency coils for MRI machines. The company also plans expansions in Pune. It spends yearly over $1.7 billion on innovation, of which 50% goes into software development. Philips also sees growth opportunities in the beauty and grooming verticals of its business in India.

The company’s group sales increased 11% to euro 4.5 billion for the third quarter of this year, and it also raised its full-year guidance to 6-7% comparable sales growth and an Adjusted EBITA margin of 10-11%.

source/content: newindianexpress.com (headline edited)

NATIONAL / KARNATAKA: MEDICAL & HEALTH CARE SERVICES: Mangaluru’s ‘First Neuro, Brain & Spine Speciality Hospital’ Conferred with ‘Best Emerging Stroke Unit in India’ Award

First Neuro, Brain & Spine Super Speciality Hospital, Mangaluru is proud to announce that it has been honoured with the prestigious award for Best Emerging Stroke Unit in India. This recognition comes in light of the hospital’s unwavering commitment to excellence in stroke care and its continuous efforts to enhance patient outcomes.

The VOH (Voice of Healthcare) in association with ISA (Indian Stroke Association) recognized First Neuro, Brain & Spine Super Speciality Hospital for its outstanding contributions to stroke care, particularly in the areas of rapid response, advanced treatments and patient-focused care and presented The Best Emerging Stroke Unit award. This acknowledgement reaffirms the hospital’s dedication to providing high-quality stroke care services to the community. Dr Mohammed Shameem K A, consultant neurologist, received the award at the event, which took place on October 27 at the Taj Skyline in Ahmedabad.

“We are deeply honoured to receive the Best Emerging Stroke Unit award,” said Dr Rajesh Shetty, managing director at First Neuro Brain & Spine Super Speciality Hospital. “This recognition is a testament to the hard work and dedication of our entire team who strive relentlessly to deliver exceptional care to our stroke patients. We remain committed to advancing our stroke care services and ensuring the best possible outcomes for our patients.”

Stroke is a leading cause of disability and death worldwide. First Neuro Brain & Spine Super Speciality Hospital is committed to raising awareness about stroke prevention, symptoms, and treatments. The hospital’s multidisciplinary team of experts, employ the latest technologies and evidence-based practices to provide comprehensive stroke care to patients, including emergency interventions, rehabilitation, and ongoing support for stroke survivors and their families.
This award serves as a validation of First Neuro Brain & Spine Super Speciality Hospital’s efforts to continuously improve its stroke care services. The hospital remains dedicated to investing in training, research, and state-of-the-art facilities to ensure that patients receive the best possible care when it matters the most.

First Neuro Brain and Spine Super-Specialty Hospital in Mangaluru is indeed a significant development in the healthcare sector for the coastal city. Neurological issues related to the brain and spine are complex and often require specialized expertise and state-of-the-art facilities for diagnosis and treatment.

Here are some potential benefits and highlights of having such a dedicated neuro hospital in the region:

Specialized Care: With a team of highly professional and specialized doctors and healthcare staff, the hospital can provide focused care for patients dealing with neurological disorders. This includes conditions such as brain tumors, spinal injuries, epilepsy, stroke, and more.
Advanced Technology: Specialized neuro hospitals typically invest in advanced medical equipment and technology to ensure accurate diagnosis and treatment. This ensures that patients have access to cutting-edge medical care.
Comprehensive Services: Neuro hospitals often offer a wide range of services, including neurosurgery, neurology, neuro-rehabilitation, and pain management. This comprehensive approach to neurological healthcare can greatly benefit patients in need.
Improving Healthcare Standards: The presence of a specialized neuro hospital can also lead to an overall improvement in healthcare standards in the region. It may encourage other medical facilities to enhance their services and competencies.
Patient Convenience: Having a dedicated neuro hospital means that patients can access specialized care in a single location, which can make the healthcare journey more convenient and less stressful.

In summary, the introduction of First Neuro Brain and Spine Super-Specialty Hospital in Mangaluru is a significant development that can enhance the region’s healthcare services, particularly in the field of neurosciences. It represents a commitment to improving patient care, advancing medical knowledge, and offering specialized treatments for neurological conditions, ultimately benefiting the local community.

For more information about First Neuro Brain & Spine Super Speciality Hospital and its stroke care services, please visit www.firstneuro.in

Email: info@firstneuro.in
Ph: 0824 2276633/0824 4293333, Mob: 9343442488

source/content: daijiworld.com (headline edited)

KARNATAKA: HEALTH & MEDICAL SERVICES / AMAZING SURGERIES :Bhagwan Mahaveer Jain Hospital Celebrates 750 Successful Scoliosis Surgeries on World Spine Day

Bhagwan Mahaveer Jain Hospital recently held a special event on World Spine Day to celebrate the achievements of the doctors in their Department of Spine and Joint Surgery. The event marked the completion of 750 successful scoliosis surgeries by the hospital.

The purpose of the event was to not only acknowledge the patients and their families, but also to recognize the medical professionals who have contributed to the success. It served as an opportunity to raise awareness about scoliosis and highlight the importance of early diagnosis and timely intervention. The hospital emphasized the fact that with the right treatment, scoliosis patients can overcome the limitations imposed by the condition.

The Chief Guest at the event, Minister for Health and Family Welfare Dinesh Gundu Rao, praised the hospital for their dedication to excellence in spinal surgeries. He stated that each successful surgery represents a life transformed from suffering to a life free from the limitations of scoliosis.

Scoliosis is a medical condition characterized by an abnormal curvature of the spine. It can cause physical deformity, pain, and discomfort. Early diagnosis and timely intervention are crucial in managing the condition effectively. The Department of Spine and Joint Surgery at Bhagwan Mahaveer Jain Hospital has been at the forefront of providing high-quality care to scoliosis patients.

The celebration of 750 successful scoliosis surgeries is a testament to the hospital’s commitment to improving the lives of individuals living with this condition. Through their expertise and dedication, the medical professionals at Bhagwan Mahaveer Jain Hospital have made a significant impact in the field of spine and joint surgeries.

Sources:
– Bhagwan Mahaveer Jain Hospital
– Minister for Health and Family Welfare Dinesh Gundu Rao

source/content: expresshealthcaremgmt.com (headline edited)

INTERNATIONAL / NATIONAL / KARNATAKA: TECHNOLOGY TRANSFER OF MEDICAL RESEARCH: Sepsis Treatment SUR-101 Developed by Researchers in Bengaluru and Bhubaneswar licensed to Dutch Biotech firm SurvivX

The development of the treatment was announced by C-CAMP director Dr Taslimarif Saiyed at an event with Netherlands PM Mark Rutte last month.

A novel sepsis treatment, called SUR-101, developed collaboratively by the Centre for Cellular and Molecular Platforms (C-CAMP), Bengaluru, and the Institute of Life Sciences, Bhubaneswar, was licensed to Dutch biotech firm SurvivX in the presence of Netherlands Prime Minister Mark Rutte on Thursday.

The development of the technology, presently at the preclinical stage, was announced by Dr Taslimarif Saiyed, director-CEO of C-CAMP, at an event with Rutte on the latter’s visit to Bengaluru on the sidelines of the G20 summit last month.

Sepsis is a life-threatening medical emergency. It happens when an infection that a patient already has triggers a chain reaction throughout the body. According to C-CAMP, existing interventions for sepsis are found to be effective only at the very early onset of sepsis. By modulating the immune response, the current technology allows a longer time window for administering targeted interventions for sepsis.

“Sepsis is a worldwide challenge, with approximately 50 million cases and 11 million sepsis-related deaths worldwide, accounting for 20 per cent of all global deaths. The new compound, called SUR-101, is an immune-stimulating therapeutic in sepsis patients with signs of immune suppression. It could be the first step towards personalization and precision in sepsis medicine that has thus far been treated as a drug discovery problem. The technology presently at the preclinical stage is a discovery by a team of scientists led by Prof Ravindran Balachandran from ILS. It has been translated and co-developed by the translational research group of Dr Saiyed at C-CAMP,” said a media release from the Bengaluru centre, which is an initiative of the Department of Biotechnology, Ministry of Science, Technology and Earth Sciences.

Speaking on the licensing effort, the Dutch ambassador to India, Marisa Gerards, said, “Life sciences & health remains a priority sector for the bilateral cooperation between the Netherlands and India. We have successfully been working in this field for many years, and this new partnership is a great example of what India and the Netherlands can do together. Sepsis is an important global societal challenge, and it is in need of innovative solutions.”

“This is one of the first global technology transfers by C-CAMP of an academic invention developed exclusively in India. We are excited about the partnership with SurvivX, a biotech company in the Netherlands, in the antimicrobial resistance domain. This agreement will be a model in innovation-focused bilateral partnerships that addresses global issues together,” Dr Saiyed said.

SurvivX CEO Remko van Leeuwen said, “Our technology is based on a specific protein excreted by a tropical parasite: the filarial roundworm. The team in India made the remarkable observation that people infected by this parasite typically do not end up at an ICU unit when they develop sepsis. They started studies to find the cause of this protective effect that an infection with this worm seems to have.”

According to Leeuwen, the researchers discovered that a specific protein secreted by the worm was responsible for the effect. “We have already shown that the protein leads to a much better survival of mice with sepsis, confirming the protective effect seen in filaria patients. But mice are not human, Thus, SurvivX needs to show the safety and activity of the protein in humans before it can be tested as a novel therapeutic approach,” he added.

source/content: indianexpress.com (headline edited)

INTERNATIONAL, NATIONAL & KARANATAKA / HEALTH & MEDICAL SERVICES : Bengaluru-based Dr Sandeep Nayak among 3 Winners of top ‘KS International Robotic Surgery Innovation Competition’ by Michigan based Foundation

Bengaluru-based robotic surgeon Dr Sandeep Nayak has been named among the three surgeons from the US and India who won top honours at the ‘KS International Robotic Surgery Innovation competition’ by Michigan-based Robotic Surgery evangelist Vattikuti Foundation.

The video entry by eminent robotic surgeon from MACS Clinic and Fortis Cancer Institute, Bengaluru was placed at the third spot for devising a novel approach for removal of thyroid tumours using minimally invasive robotic surgery.

Dr Nayak presented results of over 50 surgeries conducted over five years using this method with better patient outcomes and negligible scarring.

Robotic surgeons Dr Somashekhar SP, Aster Hospitals, Bengaluru, and Dr Aditya Kulkarni, Ruby Hall Clinic, Pune were among the top 10 vying for KS international robotic surgery award, the foundation said in a statement during the awards ceremony at Orsi Academy, Ghent, Belgium over the weekend.

“By focusing on robotic technology and surgeon education, the Vattikuti Foundation has proven the transformative power of innovative technology in revitalizing patients’ health at the hands of inventive humans,” said Raj Vattikuti, Founder, the Vattikuti Foundation.

Dr David Neal, Professor Emeritus, University of Cambridge and Oxford, Cambridge, UK; Dr Rajeev Kumar, Professor of Urology and Associate Dean (Academics), AIIMS, New Delhi; and Dr Sherry M Wren, Professor of Surgery, Stanford University, US were in the final jury that chose the top 3 from among the 141 submissions.

The video entry of Dr Adeel Khan, Washington University School of Medicine, St. Louis, demonstrating the first Robotic Liver Transplant (RLT) in the US using a deceased donor in the world was judged No 1.

The video entry of Dr Ahmed Ghazi, director of minimal invasive and robotic surgery and director of simulation training at Johns Hopkins University, US was adjudged No 2 for devising a novel patient specific simulation platform before complex robotic renal cancer surgeries.

Video submission on robot-assisted total knee transplant by Orthopaedic Surgeon Dr Suhas Masilamani, Sunshine Bone & Joint Institute and KIMS-Sunshine Hospital, Hyderabad won the people’s choice award based on rankings by surgeons from 63 countries.

Entries from procedures in 10 specialties, including urology, gynaecology, gastro-intestinal, organ transplant and head and neck, from 14 countries were received in the global competition.

source/content: daijiworld.com (headline edited)

GLOBAL: NATIONAL & KARNATAKA: With 3,797 free ECGs in 24 hours, Narayana Health sets a New Guinness World Record

On the sidelines of World Heart Day, observed on September 29, cardiologists aimed to educate people about the rising burden of cardiovascular diseases in India.

In an attempt to create awareness about cardiac health, and emphasise on the importance of regular screening for heart-related issues, Bengaluru-based Narayana Health performed 3,797 electrocardiograms (ECGs) within 24 hours, and created a Guinness World Record, on Thursday.

Dr Devi Shetty, Founder and Chairman of Narayana Health said, “Our attempt was made with the sole objective of creating awareness about health screening and the importance of regular check-ups to prevent heart diseases. It showcases the skill and dedication of our team, and we are proud to have set a new standard in cardiac care.”

On the sidelines of World Heart Day, observed on September 29, cardiologists aimed to educate people about the rising burden of cardiovascular diseases in India. They organised a camp within the hospital to perform free ECGs for people aged 18 and above.

The doctors also explained that no hospital had attempted such a record previously within a single facility. The threshold for creating the record was only 250 ECGs, which was achieved within the first few hours of the day.

ECG is a simple step performed for studying a person’s heart health. It records the electrical activity of the heart, allowing doctors to investigate further and start treatment accordingly, explained Dr Praveen Sadarmin, Consultant, Adult Cardiology, Narayana Health City. “India is already called the diabetes capital of the world, and is also likely to be the capital for cardiovascular diseases as well,” he added.

Besides substance abuse, and poor sedentary lifestyle, stress is a leading factor for heart diseases, especially among the younger generation. Citizen in the age group 30-40 are advised a annual ECG, to keep a check on heart blockages and other cardiac issues.

source/content: newindianexpress.com (headline edited)